ISS (in silico gene sequencing method) predicts phased sequences of intragenic regions, using SNPs. The key underlying idea of the method is to infer diploid sequences (a pair of phased sequences/alleles) at every functional locus utilizing the deep sequencing data from the 1000 Genomes Project and SNP data from the HapMap Project, and to build prediction models using flanking SNPs.
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Zhang XC, Zhang B, Li SS, Huang X, Hansen JA, Zhao LP
Sequencing Genes in-silico Using Single Nucleotide Polymorphisms.
BMC Genetics 2012, 13:6