i-Patch is an algorithm which given two structures and a concatenated alignment of their homologs,returns an annotation indicating propensity of surface residues to be a contact site.
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i-Patch: Inter-Protein Contact Prediction using Local Network Information
Rebecca Hamer, Qiang Luo, Judith P. Armitage, Gesine Reinert and Charlotte M. Deane
Proteins Volume 78, Issue 13, pages 2781–2797, October 2010