Indygene is a tool which reduces a supplied list of genes to one which is independent with respect to pair-wise paralogous relationships. It is intended as a data pre-processing tool to be used prior to performing Gene Class Testing (GCT) methods on microarray expression data, where the classes typically represent particular biological processes or pathways.
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BMC Bioinformatics. 2011 Jan 24;12:29. doi: 10.1186/1471-2105-12-29.
Investigating the effect of paralogs on microarray gene-set analysis.
Faure AJ1, Seoighe C, Mulder NJ.