Iccare integrates comparative sequence analysis, mapping information and primer/overgo design in order to facilitate the comparative mapping between query species (see the taxonomic tree) and completely sequenced organisms – model organisms (Homo sapiens for animals and Arabidopsis thaliana for plants). The Expressed Sequenced Tags (ESTs) and mRNA sequences of public databases of one query species are first compared to the representative transcipts of the UniGene clusters or MIPS cDNA of the model organism and the results are displayed according to the location of the genes on the chromosomes of the reference organism. Gene structure information and sequence similarities are combined in a graphical representation in order to pinpoint the nature of the transcript query sequence. Presently, the method is available for two model organisms : homo sapiens and arabidopsis thaliana and coming soon for Oryza sativa.
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Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W429-34.
The Iccare web server: an attempt to merge sequence and mapping information for plant and animal species.
Muller C, Denis M, Gentzbittel L, Faraut T.