I-TASSER was ranked best in tertiary structure prediction (as ‘Zhang-Server’) in the community-wide blind benchmarks CASP7 and CASP8. It uses mainly profile-profile comparison to identify templates and alignments for deriving distance constraints. Its power lies in how it combines the distance constraints from up to the 50 best-ranked templates. It performs some knowledge-based free modelling in regions without any template-based information.
:: MORE INFORMATION
Nucleic Acids Res. 2015 Apr 16. pii: gkv342.
I-TASSER server: new development for protein structure and function predictions.
Yang J, Zhang Y
Ambrish Roy, Alper Kucukural, Yang Zhang.
I-TASSER: a unified platform for automated protein structure and function prediction.
Nature Protocols, vol 5, 725-738 (2010)