HMM-FRAME is a protein domain classification tool based on an augmented Viterbi algorithm that can incorporate error models from different sequencing platforms. HMM-FRAME corrects sequencing errors and classifies putative gene fragments into domain families. It achieved high error detection sensitivity and specificity in a data set with annotated errors.
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BMC Bioinformatics. 2011 May 24;12:198. doi: 10.1186/1471-2105-12-198.
HMM-FRAME: accurate protein domain classification for metagenomic sequences containing frameshift errors.
Zhang Y, Sun Y.