HitWalker prioritizes patient variants relative to their weighted proximity to functional assay results in a protein-protein interaction network. It is highly extensible, allowing incorporation of diverse data types to refine prioritization.
HitWalker2 is highly flexible and can utilize many data types and prioritization methods based upon available data and desired questions, allowing it to be utilized in a diverse range of studies such as cancer, infectious disease and psychiatric disorders.
- Linux/ WIndows/MacOsX
- R Package
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HitWalker2: Visual analytics for precision medicine and beyond.
Bottomly D, McWeeney SK, Wilmot B.
Bioinformatics. 2015 Dec 26. pii: btv739
Bioinformatics. 2013 Feb 15;29(4):509-10. doi: 10.1093/bioinformatics/btt003. Epub 2013 Jan 9.
HitWalker: variant prioritization for personalized functional cancer genomics.
Bottomly D, Wilmot B, Tyner JW, Eide CA, Loriaux MM, Druker BJ, McWeeney SK.