HAPGEN simulates case control datasets at SNP markers. The new version can now simulate multiple disease SNPs on a single chromosome, on the assumption that each disease SNP acts independently and are in Hardy-Weinberg equilibrium. We also supply a R package that can simulate interaction between the disease SNPs.
- MacOsX / Linux
:: MORE INFORMATION
Chris C. A. Spencer, Zhan Su, Peter Donnelly, Jonathan Marchini (2009)
Designing Genome-Wide Association Studies: Sample Size, Power, Imputation, and the Choice of Genotyping Chip.
PLoS Genet 5(5).