GWiS (a novel Gene-Wide Significance) test uses greedy Bayesian model selection to identify the independent effects within a gene, which are combined to generate a stronger statistical signal.
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PLoS Genet. 2011 Jul;7(7):e1002177. doi: 10.1371/journal.pgen.1002177. Epub 2011 Jul 28.
Gene-based tests of association.
Huang H, Chanda P, Alonso A, Bader JS, Arking DE.