Interpreting noncoding phenotypically associated variants is an indispensable step to understand molecular mechanism of complex traits, GWAS3D systematically compute the probability of genetics variants affecting regulatory pathways and underlying disease/trait associations by integrating chromatin state, functional genomics, sequence motif, and conservation information when given GWAS data or variant list.
Bioinformatics Group, HKU Department of Biochemistry
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Nucleic Acids Res. 2013 Jul;41(Web Server issue):W150-8. doi: 10.1093/nar/gkt456.
GWAS3D: Detecting human regulatory variants by integrative analysis of genome-wide associations, chromosome interactions and histone modifications.
Li MJ, Wang LY, Xia Z, Sham PC, Wang J.