GUILD (Genes Underlying Inheritance Linked Disorders) is a network-based prioritization framework to unveil genes associated with a disease phenotype (disease-genes). The sofware exploits several communication mechanisms between disease-genes emerging from the topology of the interaction network. GUILD consists of implementations of 8 algorithms: NetScore, NetZcore, NetShort, NetCombo, fFlow, NetRank, NetWalk and NetProp.
- R package
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Guney E, Oliva B.
Exploiting Protein-Protein Interaction Networks for Genome-wide Disease-Gene Prioritization.
PLoS ONE, 2012, 7(9): e43557.