GSMA (Genome Scan Meta-Analysis) is a rank-based method to perform meta-analysis of genome-wide linkage studies. The genome is divided into equal length bins (eg 30cM). For each study, the maximum evidence for linkage within each bin is assessed, and then the bins ranked according to this information for linkage. For each bin, the ranks across studies are summed, and this summed rank forms the statistic to test for evidence of linkage within the bin. Significance is assessed using a distribution function (Wise et al, 1999), or by simulation (Levinson et al, 2003).
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Fabio Pardi et al.
GSMA: software implementation of the genome search meta-analysis method
Bioinformatics (2005) 21 (24): 4430-4431.