GraDe (graph-decorrelation) provides a novel framework for the decomposition of large-scale ‘omics’ data. Including prior knowledge into the separation task leads to a much more structured and detailed separation of the time-dependent responses upon IL-6 stimulation compared to standard methods.
Institute of Computational Biology, German Research Center for Environmental Health (GmbH)
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BMC Bioinformatics. 2010 Nov 30;11:585. doi: 10.1186/1471-2105-11-585.
Knowledge-based matrix factorization temporally resolves the cellular responses to IL-6 stimulation.
Kowarsch A, Blöchl F, Bohl S, Saile M, Gretz N, Klingmüller U, Theis FJ.