GERP++ 20110522 – Analyze Evolutionary Rates and Find Constrained Elements in a Multiple Alignment

GERP++ 20110522

:: DESCRIPTION

GERP++ (Genomic Evolutionary Rate Profiling) identifies constrained elements in multiple alignments by quantifying substitution deficits. These deficits represent substitutions that would have occurred if the element were neutral DNA, but did not occur because the element has been under functional constraint.

::DEVELOPER

Sidow Lab

:: SCREENSHOTS

N/A

:: REQUIREMENTS

  • Linux

:: DOWNLOAD

 GERP++

:: MORE INFORMATION

Citation

PLoS Comput Biol. 2010 Dec 2;6(12):e1001025.
Identifying a high fraction of the human genome to be under selective constraint using GERP++.
Davydov EV, Goode DL, Sirota M, Cooper GM, Sidow A, Batzoglou S.

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