GenomeScan is a program for identifying the exon-intron structures of genes in genomic DNA sequences from a variety of organisms, with a focus on human and other vertebrates. The algorithm combines two principal sources of information: 1) models of exon-intron and splice signal composition; and 2) sequence similarity information such as BLASTX hits.
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Yeh, R.-F., Lim, L. P., and Burge, C. B. (2001)
Computational inference of homologous gene structures in the human genome.
Genome Res. 11: 803-816.