Genes2FANs (G2F) is a web based tool and a database that utilizes 14 carefully constructed FANs and a large-scale protein-protein interaction (PPI) network to build subnetworks that connect input lists of human and mouse genes. The FANs are created from mammalian gene set libraries where mouse genes are converted to their human orthologs. The tool takes as input a list of human or mouse Entrez gene symbols to produce a subnetwork and a ranked list of intermediate genes that are used to connect the query input list. In addition, users can enter any PubMed search term and then the system automatically converts the returned results to gene lists using GeneRIF.
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BMC Bioinformatics. 2012 Jul 2;13:156. doi: 10.1186/1471-2105-13-156.
Genes2FANs: connecting genes through functional association networks.
Dannenfelser R, Clark NR, Ma’ayan A.