GEMMA (Genome-wide Efficient Mixed Model Association) tests for association in genome-wide association studies (GWAS) using a standard linear mixed model to account for population stratification and sample structure. It calculates exact Wald or likelihood ratio test statistics and p-values, and is computationally efficient for large GWAS.
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Nat Genet. 2012 Jun 17;44(7):821-4. doi: 10.1038/ng.2310.
Genome-wide efficient mixed-model analysis for association studies.
Zhou X, Stephens M.