The GEC (Genetic Type I error calculator) is a Java-based application developed to address multiple-testing issue with dependent Single-nucleotide polymorphisms (SNPs). Based on this new measure, several popular multiple-testing methods including Bonferroni, Holm, Simes correction was improved to evaluate significance level of SNP p-values in genome-wide association studies.
Miao-xin Li, The University of Hong Kong
- Windows / Linux / MacOSX
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Miao-Xin Li, Juilian M.Y. Yeung, Stacey Cherny and Pak C Sham.
Evaluating the effective numbers of independent tests and significant p-value thresholds in commercial genotyping arrays and public imputation reference datasets.
Hum Genet. 2012 May;131(5):747-56.