Gcorr corrects peptide profiles that satisfy correction conditions, and it can predict fold change null distributions at different intensity levels. Subsequently, the significance P-values of measured fold changes can be estimated based on the predicted null distributions. We have used an 1:1 LC-FTMS label-free dataset pair collected based on the same sample to verify that our predicted null distributions conforms to that of the observed null distribution.
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Proteome Sci. 2011 Oct 14;9 Suppl 1:S2. doi: 10.1186/1477-5956-9-S1-S2.
Processing methods for signal suppression of FTMS data.
Ma X1, Cui J, Zhang J.