GAME (Genetic Algorithm based Motif Elicitation)is a software which utilizes a genetic algorithm to find motifs (statistically over-represented patterns) in a set of related DNA sequences. As one application, motifs could be transcription factor binding sites in a set of co-regulated genes.
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Wei Z and Jensen ST,
GAME: Detecting Cis-regulatory Elements Using a Genetic Algorithm,
Bioinformatics, 2006 22:1577-1584,