GAM is a free parallel software tool to integrate two different assemblies and improves the overall quality of the genome sequences by merging them. It discovers and align similar sequences by using the positions of placed reads. An order sequence of reads contiguous on the same contig is called frame. When the same frame is shared by both original assemblies, GAM dubs it block.
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A. Casagrande, C. Del Fabbro, S. Scalabrin, A. Policriti.
GAM: Genomic Assemblies Merger. A Graph Based Method to Integrate Different Assemblies
Proceedings of the Third IEEE International Conference on Bioinformatics & Biomedicine (BIBM 2009), Washington D.C. (USA), November 1-4 2009.