FusionAnalyser is a software for detecting gene fusions from paired-end RNA-Seq data.FusionAnalyser uses paired reads mapping to different genes (Bridge reads), generated through high-throughput whole transcriptome sequencing, to build a first dataset of candidate fusion events. Subsequently, a second dataset, built upon those reads where only one of the two sequences in a pair is successfully mapped to the reference genome (‘Half-mapped Anchor reads’), is generated. The mapped reads in the latter dataset are used as an anchor to tie each Half-mapped event to the corresponding Bridge region.
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Nucleic Acids Res. 2012 Sep 1;40(16):e123. Epub 2012 May 8.
FusionAnalyser: a new graphical, event-driven tool for fusion rearrangements discovery.
Piazza R, Pirola A, Spinelli R, Valletta S, Redaelli S, Magistroni V, Gambacorti-Passerini C.