FreeNA is a PC computer program which performs three major tasks on any microsatellite dataset harboring null alleles: (1) it estimates null allele frequencies for each locus and population analysed following the Expectation Maximization (EM) algorithm of Dempster, Laird, and Rubin (1977); (2) it estimates unbiased FST (Weir 1996) following the ENA method described in Chapuis and Estoup (2007); (3) it calculates the Cavalli-Sforza and Edwards (1967) genetic distance following the INA method described in Chapuis and Estoup (2007). All methods used in this program are tested and discussed in Chapuis and Estoup (2007).
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Chapuis, M.P., and A. Estoup. 2007.
Microsatellite null alleles and estimation of population differentiation.
Mol. Biol. Evol. 24(3): 621-631.