freeIbis offers significant improvements in sequence accuracy owing to the use of a novel multiclass support vector machine (SVM) algorithm. Sequence quality scores are now calibrated based on empirically observed scores, thus providing a high correlation to their respective error rates. These improvements result in downstream advantages including improved genotyping accuracy.
Department of Genetics / Bioinformatics Group, Max Planck Institute for Evolutionary Anthropology, Leipzig
- Windows / MacOsX / Linux
- C++ compiler
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Renaud G, Kircher M, Stenzel U and Kelso J.
freeIbis: an efficient basecaller with calibrated quality scores for Illumina sequencers.