FREAD is a database search loop structure prediction protocol. Loops are generally located in the protein’s surface and they are known to be notoriously difficult to predict.The basic assumption of FREAD is that local sequence similarity may determine the backbone structure of a local protein structure if it is constrained within anchor structures.
FREAD revisited: Accurate loop structure prediction using a database search algorithm.
Choi Y, Deane CM.
Proteins. 2010 May 1;78(6):1431-40. doi: 10.1002/prot.22658.