FOCAL (Fast Optimized Cluster Algorithm for Localizations) is a rapid density based algorithm for detecting clusters in localization microscopy datasets. FOCAL is easily optimized to reduce artifacts that commonly degrade image reconstructions and minimize the detection of false or pseudo clusters.
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Fast Optimized Cluster Algorithm for Localizations (FOCAL): A Spatial Cluster Analysis for Super-Resolved Microscopy.
Mazouchi A, Milstein JN.
Bioinformatics. 2015 Nov 4. pii: btv630.