The FindEM program is based on projection matching using local real-space correlation with a series of templates. Real-space algorithms are traditionally relatively slow, but a fast Fourier based implementation of the real-space local correlation function has been introduced which is approximately two orders of magnitude faster for the projection matching application.
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J Struct Biol. 2004 Jan-Feb;145(1-2):91-9.
FindEM–a fast, efficient program for automatic selection of particles from electron micrographs.