The FDM (Flow Difference Metric) identifies regions of differential RNA-transcript expression between pairs of splice graphs, without need for an underlying gene model or catalog of transcripts. We present a novel non-parametric statistical test between splice graphs to assess the significance of differential transcription, and extend it to group-wise comparison incorporating sample replicates.
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Darshan Singh, et al
FDM: A Graph-based Statistical Method to Detect Differential Transcription using RNA-seq data
Bioinformatics (2011) doi: 10.1093