FastER is a software for identifying orthologous gene pairs that appear to have fast-evolving regions between two closely related genomes. Its input can be either two closely related whole genome sequences or two closely related orthologous sequences. It consists of two steps: first, it will detect all regions with overrepresented nonsynonymous mutations; second, it will test the nonsynonymous evolution rate against the neutral evolution rate in that gene.
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Identification of genes with fast-evolving regions in microbial genomes
Yu Zheng, Richard J. Roberts and Simon Kasif
Nucl. Acids Res. (2004) 32 (21): 6347-6357.