Evigan is an automated gene annotation program for eukaryotic genomes, employing probabilistic inference to integrate multiple sources of gene evidence. The probabilistic model is a dynamic Bayes network whose parameters are adjusted to maximize the probability of observed evidence. Consensus gene predictions are then derived by maximum likelihood decoding, yielding n-best models (with probabilities for each).
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Evigan: a hidden variable model for integrating gene evidence for eukaryotic gene prediction.
Liu Q, Mackey AJ, Roos DS, Pereira FC.
Bioinformatics. 2008 Mar 1;24(5):597-605. Epub 2008 Jan 10.