ESTScan is a program that can detect coding regions in DNA/RNA sequences, even if they are of low quality (e.g. EST sequences). ESTScan will also detect and correct sequencing errors that lead to frameshifts. ESTScan is not a gene prediction program , nor is it an open reading frame detector. In fact, its strength lies in the fact that it does not require an open reading frame to detect a coding region. As a result, the program may miss a few translated amino acids at either the N or the C terminus, but will detect coding regions with high selectivity and sensitivity.
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Lottaz C, Iseli C, Jongeneel CV, Bucher P. (2003)
Modeling sequencing errors by combining Hidden Markov models
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Iseli C, Jongeneel CV, Bucher P. (1999)
ESTScan: a program for detecting, evaluating, and reconstructing potential coding regions in EST sequences.
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