EPDT (Extended Pedigree Disequilibrium Test) is a major advancement in detecting linkage/disequilibrium signals between genetic markers and disease loci, particularly if only one or a few large pedigrees are available. The strategy differs from conventional approaches that require at least a moderate number of families to attain adequate statistical power. The proposed testing procedure is advantageous in that it provides high statistical power coupled with reduced sample collection. Furthermore, the proposed method avoids problems such as potential population stratification and genetic heterogeneity, and is robust with respect to misspecification of phenotype.
Chun-Liang Chen, Cathy SJ Fann(Institute of Biomedical Sciences, Academia Sinica, Taiwan)
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H.C. Yang, C.L. Chen, and C.S.J. Fann (2004).
A pedigree-based disequilibrium test for a single extended pedigree