EBVariant is an optimal empirical Bayes testing procedure to detect variants for NGS study. It exploits the across-site information among vast amount of testing sites in Next Generation Sequencing data, and thus, comparing to conventional Bayesian models or frequestist tests, EBVariant is able to address the multiplicity and testing efficiency issues simultaneously.
- R package/Java
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Zhao Z, Wang W, and Wei Z.
An empirical Bayes testing procedure for detecting variants in analysis of next generation sequencing data.
Annals of Applied Statistics, accepted.