easyLINKAGE is a joint project of the Institute of Human Genetics, Charité Virchow Campus Berlin and the Division of Nephrology, Department of Medicine, Neurology, and Dermatology, University Clinic Medical Leipzig. We extended the original easyLINKAGE program by enabling linkage analyses for large-scale SNP data in addition to those of microsatellites. We implemented new modules for Allegro, Merlin, SimWalk, GeneHunter Imprinting, GeneHunter TwoLocus, SuperLink and extended FastSLink by automatic loop breaking and new outputs. We added conditional linkage analyses as well as multipoint simulation studies, and extended error test routines by checking for Mendelian/non-Mendelian genotyping errors and for deviations from Hardy–Weinberg equilibrium. Data can be analyzed in sets of markers, in defined centimorgan intervals and by using different allele frequency algorithms. The outputs consist of genome-wide as well as chromosomal postscript plots of LOD scores, NPL scores, P-values and other parameters.
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Bioinformatics. 2005 Feb 1;21(3):405-7. Epub 2004 Sep 3.
easyLINKAGE: a PERL script for easy and automated two-/multi-point linkage analyses.
Lindner TH, Hoffmann K.