DPS (Drug Pair Seeker) is a Java program that attempts to predict and prioritize pairs of drugs using the Connectivity Map dataset. Users can enter lists of up and down differentially expressed genes from their experiments to receive a ranked list of drug combinations that are predicted to either reverse or aggravate the gene expression state of the cells or tissue of interest using a simple formula.
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Zhong Y, Chen EY, Liu R, Chuang PY, Mallipattu SK, Tan CM, Clark NR, Deng Y, Klotman PE, Ma’ayan A, He JC.
Renoprotective effect of combined inhibition of angiotensin-converting enzyme and histone deacetylase.
J Am Soc Nephrol. 2013 Apr;24(5):801-11