DoBo (Domain Boundary) is a tool to identify domain boundaries from sequence. It works by combining the classification power of machine learning with domain boundary signals embedded in multiple sequence alignments.
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BMC Bioinformatics. 2011 Feb 1;12:43. doi: 10.1186/1471-2105-12-43.
DoBo: Protein domain boundary prediction by integrating evolutionary signals and machine learning.
Eickholt J1, Deng X, Cheng J.