DIRAC (Differential Rank Conservation) is a software which permits one to assess these combinatorial interactions to quantify various biological pathways or networks in a comparative sense, and to determine how they change in different individuals experiencing the same disease process.
the Price lab at ISB
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Identifying tightly regulated and variably expressed networks by Differential Rank Conservation (DIRAC).
Eddy JA, Hood L, Price ND, Geman D.
PLoS Comput Biol. 2010 May 27;6(5):e1000792.