DeterminePPI aims to infer protein-protein interaction by parsimony principle. Specifically, inferring domain interactions is formulated as an integer linear programming and solved by relaxed linear programming. In contrast to probabilistic algorithms, DeterminePPI is an algorithm based on a deterministic model.
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Chen C, Zhao JF, Huang Q, Wang RS, Zhang XS.
Inferring domain-domain interactions from protein-protein interactions in the complex network conformation.
BMC Syst Biol. 2012;6 Suppl 1:S7. doi: 10.1186/1752-0509-6-S1-S7.