Delila-genome is a software system for identification, visualization and analysis of protein binding sites in complete genome sequences. Binding sites are predicted by scanning genomic sequences with information theory-based (or user-defined) weight matrices. Matrices are refined by adding experimentally-defined binding sites to published binding sites. Delila-Genome was used to examine the accuracy of individual information contents of binding sites detected with refined matrices as a measure of the strengths of the corresponding protein-nucleic acid interactions. The software can then be used to predict novel sites by rescanning the genome with the refined matrices.
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BMC Bioinformatics. 2003 Sep 8;4:38. Epub 2003 Sep 8.
Genome-wide prediction, display and refinement of binding sites with information theory-based models.
Gadiraju S, Vyhlidal CA, Leeder JS, Rogan PK.