The modified DAS method, the DAS-TMfilter algorithm, has an unchanged high sensitivity for TM segments ( approximately 95% detected in a learning set of 128 documented transmembrane proteins). At the same time, the selectivity measured over a non-redundant set of 526 soluble proteins with known 3D structure is approximately 99%, mainly because a large number of falsely predicted single membrane-pass proteins are eliminated by the DAS-TMfilter algorithm.
:: MORE INFORMATION
TM or not TM: transmembrane protein prediction with low false positive rate using DAS-TMfilter.
Cserzo M, Eisenhaber F, Eisenhaber B, Simon I.
Bioinformatics. 2004 Jan 1;20(1):136-7.