CycSim is a web application dedicated to in silico experiments with genome-scale metabolic models coupled to the exploration of knowledge from BioCyc and KEGG. Specifically, CycSim supports the design of knockout experiments: simulation of growth phenotypes of single or multiple gene deletions mutants on specified media, comparison of these predictions with experimental phenotypes and direct visualization of both on metabolic maps.
Computational Systems Biology Group, Genoscope – Institut de Génomique – CEA
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Bioinformatics. 2009 Aug 1;25(15):1987-8. doi: 10.1093/bioinformatics/btp268. Epub 2009 May 6.
CycSim–an online tool for exploring and experimenting with genome-scale metabolic models.
Le Fèvre F, Smidtas S, Combe C, Durot M, d’Alché-Buc F, Schachter V.