CUPSAT (Cologne University Protein Stability Analysis Tool) is a tool to predict changes in protein stability upon point mutations. The prediction model uses amino acid-atom potentials and torsion angle distribution to assess the amino acid environment of the mutation site. Additionally, the prediction model can distinguish the amino acid environment using its solvent accessibility and secondary structure specificity.
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Parthiban V, Gromiha MM and Schomburg D. (2006)
CUPSAT: prediction of protein stability upon point mutations.
Nucleic Acids Research, 34, W239-42.