CRML (C. elegans Muscle Cis-Regulatory Module Locator) is a web tool for predicting cis-regulatory modules that direct muscle-specific gene expression in C. elegans. CRML makes high quality predictions with a sensitivity of 88% and a positive predictive value of at least 65%. In vivo experimental tests of 12 predicted modules show that 10 of those drive muscle-specific gene expression. These results suggest that CRML is highly accurate in identifying functional sequences important for muscle-specific gene expression and is a valuable tool for guiding experimental designs.
Stormo Lab in Department of Genetics, Washington University
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Guoyan Zhao, Lawrence A. Schriefer and Gary D. Stormo (2007)
Identification of Muscle-Specific Regulatory Modules in Caenorhabditis elegans.
Genome Research. 17:348-357