CpGpromoter is a program for a large-scale human promoter mapping using CpG islands. As defined by Gardiner-Garden & Frommer, CpG islands are greater than 200 bp in length, have more than 50% of G+C content, and have a CpG frequency of at least 0.6 of that expected on the basis of the G+C content of the region. CpG islands are an important signature of 5′ region of many mammalian genes. The program is based on results of discriminant analysis between the promoter-associated CpG islands and non-associated ones (Ioshikhes & Zhang). It enables an efficient mapping of human promoters with 2Kb resolution, if there is a CpG island inside an interval (-500…+1,500) around a transcription start site (TSS).
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Ioshikhes, I. & Zhang, M.Q.
Large-scale human promoter mapping using CpG islands.
Nature Genetics 26, 61-63 (2000)