CotQuest is specifically tailored to conduct nonlinear regression analysis of DNA reassociation kinetics (i.e., Cot) data when used with the statistics package SAS. CotQuest is unique in that it does not require users to input guesses as to the final values of parameters. The CotQuest program surpasses all existing Cot analysis programs with regard to automation, statistical robustness, user-friendliness, and graphical output.
the Mississippi Genomics Exploration Laboratory (MGEL) ,Mississippi State University,
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Anal Biochem. 2009 May 15;388(2):322-30. doi: 10.1016/j.ab.2009.03.007.
CotQuest: improved algorithm and software for nonlinear regression analysis of DNA reassociation kinetics data.
Bunge J, Chouvarine P, Peterson DG.