COTH (CO-THreader) is a multiple-chain protein threading algorithm which is designed to identify and recombine protein complex structures from both tertiary and complex structure libraries. It first generates complex query-template alignments based on sequence profile-profile alignment assisted by the ab initio binding-site predictions from BSpred. The monomer structures from tertiary template library are then combined into the complex framework by structure superposition
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Structure. 2011 Jul 13;19(7):955-66. doi: 10.1016/j.str.2011.04.006.
Protein-protein complex structure predictions by multimeric threading and template recombination.
Mukherjee S1, Zhang Y.