ComSeq is a set of utilities used for simulating and analyzing compressed-sensing pooling design experiments for next-generation sequencing projects. The aim is to identify novel rare alleles, or detect individuals who are carriers of known SNPs in a large population. The package enables an in-silico simulation of a sequencing pooling experiments, including modeling of sequencing error parameters. The package also enables reconstructing genotypes of individuals profiled in real experiments.
- Linux / Mac OsX / Windows
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Identification of Rare-Alleles And Their Carriers Using Compressed Se(que)nsing
N. Shental, A. Amir and O. Zuk,
Nucleic Acid Research (2010)