Comrad is a novel algorithmic framework for the integrated analysis of RNA-Seq and Whole Genome Shotgun Sequencing (WGSS) data for the purposes of discovering genomic rearrangements and aberrant transcripts. The Comrad framework leverages the advantages of both RNA-Seq and WGSS data, providing accurate classification of rearrangements as expressed or not expressed and accurate classification of the genomic or non-genomic origin of aberrant transcripts.
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Andrew McPherson, Chunxiao Wu, Iman Hajirasouliha, Fereydoun Hormozdiari, Faraz Hach1, Anna Lapuk, Stanislav Volik, Sohrab Shah, Colin Collins and S. Cenk Sahinalp
Comrad: a novel algorithmic framework for the integrated analysis of RNA-Seq and WGSS data
Bioinformatics (2011)doi: 10.1093/bioinformatics/btr184