CLUSTOM that is categorized into hierarchical clustering approach is a program for clustering high-throughput 16S sequences with user-defined thresholds.
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CLUSTOM: a novel method for clustering 16S rRNA next generation sequences by overlap minimization.
Hwang K, Oh J, Kim TK, Kim BK, Yu DS, Hou BK, Caetano-Anollés G, Hong SG, Kim KM.
PLoS One. 2013 May 1;8(5):e62623. doi: 10.1371/journal.pone.0062623