CLAIM (CLuster Analysis Integration Method) is a new method for integrating co-expression data obtained through microarray experiments (MA) and protein-protein interaction (PPI) network data. Microarray and PPI data are separately clustered; the clusters are then merged in a special graph; cliques of this graph would identify a group of functionally related proteins. The biological insight provided by these groups is analyzed on the basis of co-localization and mRNA developmental expression, pointing out the new information that can be obtained by this method.
The Bioinformatics Group, Poznan University of Technology.
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OMICS. 2014 Feb;18(2):155-65. doi: 10.1089/omi.2013.0050. Epub 2014 Jan 3.
An integrated approach (CLuster Analysis Integration Method) to combine expression data and protein-protein interaction networks in agrigenomics: application on Arabidopsis thaliana.
Santoni D1, Swiercz A, Zmieńko A, Kasprzak M, Blazewicz M, Bertolazzi P, Felici G.